Endocrine Abstracts

Introduction: Cortisol activates lipolysis in adipose tissue resulting in the release of free fatty acids into the circulation, it also activates cholesterol and triglycerides synthesis. The consequence is an increase in total circulating cholesterol and triglycerides with their inherent risks on the cardiovascular system. The aim of our work was to assess the prevalence and characteristics of dyslipidaemia in Cushing’s syndrome (CS).Material and me...

Introduction: Patients with Cushing’s syndrome (CS) are prone to hypertension as cortisol stimulates renal reabsorption of sodium and enhances vascular sensitivity to catecholamine and angiotensin II. This explains the frequency of hypertension in patients with CS. The aim of our work was to assess the prevalence and characteristics of hypertension in CS.Material and methods: This is a retrospective study concerning 51 CS (44F/7M) in whom we looked ...

Introduction: Brain metastases of thyroid carcinomas are rare (0.1–5%) according to the literature data. They generally occur in a context of metastatic spread which has a serious impact on survival. We report two cases and will review the literature data.Observations: Case 1: 57-year-old patient monitoring for papillary thyroid carcinoma in its solid form trabecular classified T4N0M1with lung metastases. Following a neurological symptoms of tonic-c...

Introduction: Papillary thyroid carcinoma (PTC) has generally good prognosis, and distant spread is rare. Common sites of distant metastasis are lung parenchyma and bone. Pleural metastasis is less common (0.6%), and most cases have been detected because of pleural effusion. Malignant pleural effusion is a poor prognostic factor among patients with PTC. We report a case of pleural metastasis of PTC proved by pleural biopsy.Case report: A 62-year-old man ...

Introduction: Pituitary apoplexy is a rare endocrine emergency characterized by the sudden onset of severe headaches, vomiting, visual abnormalities and pituitary dysfunction secondary to an acute hemorrhage or infarction within a pituitary adenoma.Subjects and methods: We report a retrospective study from 2000 to 2014 of 23 cases with pituitary apoplexy. Their mean age was 38.7±14.8 years, with a male to female ratio of 2:1.R...

Klinefelter’s syndrome (KS) is the most frequent form of sex chromosome aneuploidy. The classic form of KS is associated with a 47,XXY karyotype. Mosaic forms of KS are thought to occur in approximately 10% mainly in the form of 46,XX/47,XXY. Other forms of mosaicism are rare among which the 46,XX/47,XXY form is very rare and can manifest as an ambiguous genitalia at birth as reported in our case.A full term child presented at birth an hypospadias w...

Insulinoma is the most common cause of hypoglycemia related to endogenous hyperinsulinism in adults. It is very rare in pregnancy, fewer than 30 cases of insulinoma presenting in pregnancy have been reported so far and it’s managment is very challenging. We raported here the case of a pregnant women aged 35 years presenting an insulinoma.The diagnosis was made 1 year ago in the presence of hypoglycemia, high levels of inulin and C-peptide and a 10 m...

Introduction: Abnormalities of midline (AML) can be isolated or to be associated to secretory pituitary abnormalities that reflect a developmental defect of the hypothalamic pituitary (HP) region.Aim: Find AML in GH deficiency (GHD) and see their relationship with the appearance of the HP region and the severity of hypopituitarism (I P).Population and methodology: 160 children (141 ♂, ♀ 19) (IGH) underwent a clinical ex...

Lymphoma adrenal is a rare cause of adrenal tumor (0.5%). Bilateral primary lymphoma adrenal phenotype T is exceptional. We report two observations. MO 56 years old was hospitalized FOR exploration and therapeutic management of two large adrenal masses discovered on CT imaging after back pain, and weight loss. Physical examination revealed a patient asthenic, with no signs of hypersecretion. The rest of the examination was unremarkable and research call signs primary neoplasm ...

Introduction: Suppurative meningitis (SM) is a life threatening disease. It is rarely observed as a primary presentation in large pituitary tumours (PT) destroying the sellar floor and/or invading the skull base. Our aim is to report 3 SM revealing macroprolactinomas.Case No. 1: A man aged 22, consulted for vomiting and fever. The diagnosis of SM was confirmed by lumbar puncture and blood cultures. Cerebral MRI showed multidirectional PT invading caverno...